亚洲一区亚洲二区亚洲三区,国产成人高清在线,久久久精品成人免费看,999久久久免费精品国产牛牛,青草视频在线观看完整版,狠狠夜色午夜久久综合热91,日韩精品视频在线免费观看

Synthesis of 4-Aminosalicylglycine

時(shí)間:2023-04-26 14:54:56 數(shù)理化學(xué)論文 我要投稿
  • 相關(guān)推薦

Synthesis of 4-Aminosalicylglycine

To search for a better prodrug of 4-aminosalicylic acid that is expected to deliver stably parent drug to colon against the inflammatory bowel disease, a novel 4-aminosalicylic acid derivative was designed and synthesized from 4-aminosalicylic acid. 4-Aminosalicylglycine was prepared from 4-aminosalicylic acid by protecting amino and hydroxyl groups with benzyloxycarbonyl and acetyl, respectively, then the carboxylic acid was converted to acyl chloride which was treated with glycine. After removing the protection groups, 4-aminosalicylglycine was obtained. All the compounds were characterized by FT-IR, 1H-NMR, 13C-NMR spectra. In vivo experiment on rats suggested that the curative effect of 4-aminosalicylglycine was more effective than that of 4-aminosalicylic acid.

作 者: Zheng Bao ZHAO JING GUO Yuan Gui WEI Tong Da LIANG   作者單位: College of Pharmacy, Shanxi Medical University, Taiyuan 030001  刊 名: 中國(guó)化學(xué)快報(bào)(英文版)  ISTIC SCI 英文刊名: CHINESE CHEMICAL LETTERS  年,卷(期): 2005 16(7)  分類號(hào): O6  關(guān)鍵詞: 4-Aminosalicylio acid   4-aminosalicylglycine   inflammatory bowel disease